A Conversation with Dr Mhairi Morris Exploring How Exercise Shapes Cancer Biology in 3D
Dr Mhairi Morris, Senior Lecturer at Loughborough University, investigates how exercise influences breast cancer within the School of Sport, Exercise and Health Sciences. In this short video, she explains how her team has developed a 3D model of the obesogenic tumour microenvironment, using visceral and subcutaneous fat cells to study how different adipocyte types affect cancer cell behaviour and how these responses change when exercise is introduced.
To generate reliable viability data in these complex systems, Mhairi uses the CellTiter-Glo® 3D Cell Viability Assay, highlighting its reproducibility, ease of use and suitability for matrix-embedded cultures. She also incorporates the Lumit® hKi-67 Immunoassay to gain complementary insights into cancer cell proliferation.
Furthermore, Dr Morris discusses the importance of using 3D models to capture realistic tumour biology and shares early findings showing that adipocytes increase cancer cell viability, while exercise reduces this effect. Her team is now working to uncover the mechanisms driving these exercise-related changes.
Learn more about CellTiter-Glo® 3D Cell Viability Assay
Download the: Tools to Monitor Biology in 3D Culture flipbook
