Professor Paul Horrocks from Keele University Outlines the use of Firefly Luciferase as a Dynamic Reporter Tool to Investigate
Drug Action
In order to investigate potential antimalarials for their pharmacological properties, Professor Horrocks’ group have developed a bioluminescent assay that uses firefly luciferase as a reporter tool due to its sensitivity and dynamic response, which are critical for determining rate of kill. The additional advantages of being robust and easy to use make this firefly reporter assay ideal for scaling up to high-throughput screening for antimalarial drug development.
In this case study, Paul Horrocks, Professor of Molecular Parasitology at Keele University, discusses his research focused on the biology of the human malarial parasite P. falciparum and understanding the dynamics of drug action. There is an urgent demand for new antimalarial medicines that are both potent and fast-acting, and Professor Horrocks’ lab group is running assays to find potential drugs with both of these properties.
See more about Professor Horrocks’ research >
Learn more about Luciferase Assays >
Professor Horrocks’ research focuses on the human malarial parasite P. falciparum.
You can also view this video on YouTube