GloResponse™ CRE-luc2P HEK293 Cell Line Technical Bulletin

Literature # TB362

The GloResponse™ CRE-luc2P HEK293 Cell Line is a clonal derivative of Human Embryonic Kidney 293 cells. These cells contain a luciferase gene (luc2P) under the control of a minimal Herpes Simplex Virus (HSV) thymidine kinase promoter with multiple cAMP response elements (CREs). CRE is the DNA-binding sequence for the transcription factor CRE binding protein (CREB), which is responsible for regulation of a variety of biological functions including cell proliferation, circadian rhythms and memory. The GloResponse™ CRE-luc2P HEK293 Cell Line is designed for rapid and convenient analysis of any cellular response that results in modulation of CREB activities.