Promega Corporation

Experience the Power of a Single Tag

The HaloTag® technology is a comprehensive platform for functional protein analysis. It is based on the formation of a covalent bond between a protein fusion tag (HaloTag®) and synthetic chemical ligands. By interchanging different synthetic ligands researchers ultimately control the function and properties of the HaloTag® fusion protein. The HaloTag® system is designed to provide broad experimental flexibility and superb performance in both cell-based and biochemical assays without switching fusion tags, or recloning. Available HaloTag® ligands include magnetic and non-magnetic beads, glass slides, cell-permeable and impermeable fluorescent ligands, biotin, and reactive ligands to enable researchers to build their own custom HaloTag® ligands and surfaces. The diversity of HaloTag® ligands allows a large number of different applications including, protein purification, protein interaction discovery, protein arrays, cell-based assays for protein translocation, receptor internalization, protein stability.

HaloTag® Solutions

2013 Breakthrough Discoveries in Epigenetics Using HaloTag® Technology

"KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors"

Black, J. et al. (2013) Cell, 154 (3), 541-55.

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"HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia"

Galbraith et al. (2013) Cell, 153 (6), 1327-39.

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"TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS"

Deplus, R. et al. (2013). EMBO J. 32, 645–50.

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